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In obese men, the dramatically increased volume of adipose tissue produces excess aromatase, tipping the balance toward estrogen dominance
These signals exert their metabolic regulatory effects by independently or interactively transmitting through subsets of the vagus nerve or by directly crossing the blood-brain barrier into the CNS [3](Fig
Fan H, Li TF, Gong N, Wang YX (2016) Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis Rotata, reduces neuropathic pain by stimulating spinal microglial -endorphin expression
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